Research objectives of the Senge group at Trinity College, Dublin

Synthetic Porphyrin Chemistry

Our group is active in developing the organic chemistry, biochemistry, and applications of porphyrins and related macrocycles.

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Structural Chemistry

We characterize novel compounds by single-crystal X-ray diffractometry, to determine atomic structure and intermolecular interactions, pioneering methods in data science and in structure-property-activity relationships.

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Photomedicine and PDT

Polypyrrole-derived molecules and formulations thereof can be applied for anti-cancer and anti-microbial photodynamic therapies. Photosensitizers possess a wide range of functionalities for targeting and biocompatibility.

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Sensing and Photoremediation

Porphyrin molecules can be used as colorimetric components for sensing systems; the Senge group is researching porphyrin-based sensors for selective ion and chiral molecule quantification.

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Rigid Scaffolds

The rigid, saturated alkanes cubane, bicyclo[2.2.2]octane and bicyclo[1.1.1]pentane are customizable scaffolds for novel drug syntheses and materials applications. We are exploring the fundamental organic chemistry of these rigid molecules.

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The Senge group has received funding from many national and international funding bodies.

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